Welcome!

Our group investigates the design and manufacture of self-assembled and crystalline materials using innovative approaches for process control, integration, and model-based optimization. Typical applications involve high value-added products such as pharmaceuticals and advanced materials that are functionalized by tiny structural features. Our approach is both computational and experimental. The former typically includes model-based design and optimization studies whereas the latter involves experimental validation of novel concepts for process design, integration, and control.

Meet our group members, read more about our research, have a look at our publications, read the news, or join us!

People

Richard Lakerveld

Richard Lakerveld

Principal Investigator

Email: r.lakerveld@ust.hk
Room: CYT2003
Phone: (852) 3469 2217
Google Scholar: w6b8BHwAAAAJ
Scopus ID: 55927970800
Faculty page

Richard Lakerveld is an Assistant Professor in the Department of Chemical and Biological Engineering (CBE) at The Hong Kong University of Science and Technology (HKUST). Furthermore, he is an Honorary Assistant Professor in the Department of Pharmacology and Pharmacy at The University of Hong Kong (HKU). He joined the CBE department of HKUST in October 2014. He was an Assistant Professor at Delft University of Technology for 2 years before joining the faculty of HKUST. Prior to that, he worked for 2 years as Postdoctoral Associate at the Process Systems Engineering Laboratory of the Massachusetts Institute of Technology in the group of Paul Barton. At MIT, he worked on plant-wide control of continuous pharmaceutical manufacturing and on optimal control of directed self-assembly. He received his chemical engineering education from Delft University of Technology where he obtained both his MSc with honors track and PhD degree cum laude. His PhD research involved the development of a task-based design approach for solution crystallization processes under supervision of Johan Grievink, Peter Jansens, and Herman Kramer. Furthermore, he was the recipient of an NWO Veni Award in 2013, which is an early career award from the Dutch Science Foundation. His other personal awards include a VNCI award, the Novartis-MIT Enabling Control System Award, and four consecutive GRF Awards from Hong Kong's Science Foundation, which are competitive personal grants aimed at supporting cutting-edge research. He also received the School of Engineering Teaching Excellence Appreciation Award and is a member of the 2019 Class of Influential Researchers of the journal Industrial & Engineering Chemistry Research. His research interests are in the field of Process Systems Engineering with a focus on the design and manufacture of crystalline and self-assembled materials. When time permits, he likes to take his bike for a road trip or spend some time on the football pitch.

Madiha Nisar

Dr. Madiha Nisar

Postdoctoral Associate

Email: mnisar@connect.ust.hk
Room: CYT2007B

Madiha joined the Lakerveld Lab as a Postdoctoral Fellow in September 2019. She completed her PhD in Prof. Ian D. Williams group at the Department of Chemistry, HKUST, Hong Kong. Her thesis focused on the development of Antimalarial compounds and cocrystals based on 11-Azaartemisinin (derivative of a traditional Chinese medicine (TCM), Artemisinin). She was awarded a Research travel award by American Crystallographic Association (ACA) for presenting her research at 67th annual meeting of ACA in New Orleans, in 2017. During her PhD, she acquired a broad expertise in the areas of crystal engineering, characterization techniques, organic synthesis and single crystal X-ray diffraction. She is currently working on the pharmaceutical crystallization of TCMs. She is also a nature enthusiast, loves travelling, photography and videography.

Kiran Mathew Thomas

Kiran Mathew Thomas

Postgraduate Student

Email: kiran.mathew.thomas@connect.ust.hk
Room: CYT2007B

Kiran joined the Lakerveld Lab in August 2016. He graduated from VIT University, India, in 2012 with a Bachelor degree in Mechanical Engineering. He obtained his MSc degree in Process and Energy Engineering in 2014 from Delft University of Technology, The Netherlands. He held several internship position in Process and Energy companies around the world and his MSc graduation research work has been published in a prestigious academic journal. He is currently working on new experimental concepts for continuous pharmaceutical crystallization. In his leisure time, he enjoys travelling and solving puzzles.

Baggie Waponde Nyande

Baggie Waponde Nyande

Postgraduate Student

Email: bwnyande@connect.ust.hk
Room: CYT2001

Baggie joined the Lakerveld Lab in September 2017. He graduated from the Department of Chemical and Materials Engineering at the Kwame Nkrumah University of Science and Technology in Ghana in 2014 with first-class honors. After his undergraduate studies, he obtained an Master degree from the Department of Chemical and Biological Engineering at Hanbat National University in Korea at the top of his class. He is the recipient of the prestigious HKPFS award from the Hong Kong government to attract top-notch postgraduate students to Hong Kong. He is working on automated control of directed self-assembly processes. In his spare time, he likes to play football and reading about geopolitics.

Ruipeng Chen

Ruipeng Chen

Postgraduate Student

Email: rchenar@connect.ust.hk
Room: CYT2007B

Ruipeng Joined the Lakerveld group in June 2018. He graduated from Tongji University in 2013 with a bachelor degree in applied chemistry, he obtained several scholarships and student union awards, ranking 5% in his deparment, for which he was admitted as a master student of Tongji University without the entrance exam. He completed his master degree in 2016 and his master thesis focus on the self-asembly of DNA origami. He is currently working on protein crystallization in continuous flow. In his spare time, he likes to play basketball and watch science fiction movies. He's a big fan of the Houston Rockets of NBA.

Xiaojin Xu

Xiaojin Xu

Postgraduate Student

Email: xxuan@connect.ust.hk
Room: CYT2001

Xiaojin joined the Lakerveld Lab in September 2018. He graduated from Sun Yat-Sen University in 2016 with a Bachelor degree in Chemical Engineering and Technology. Afterwards, he obtained his Master degree from the Department of Chemical and Biological Engineering in HKUST in early 2018. During his Msc studies, he received an Excellent Student Scholarship and participated in a research internship programme related to molecular dynamics in Spanish National Research Council for 6 months. He is currently working on design and optimization of DNA self-assembly. In his leisure time, he enjoys watching movies and travelling around.

Soojin Kwon

Soojin Kwon

Postgraduate student

Email: sjkwon@connect.ust.hk
Room: CYT2007B

Soojin joined the Lakerveld Lab in August 2018. She obtained both BSc and MSc in Chemical Engineering from Inha University, South Korea in 2016 and 2018, respectively. She ranked the first in her department when she graduated from undergraduate school and received academic scholarships during her studies. Her MSc works involved development of mathematical model for process system such as membrane, reactor, etc. She is currently working on continuous pharmaceutical process intensification. In spare time, she enjoys running, riding her bike and other sports.

Pramuditha Mendis

Nethrue Pramuditha Mendis

Postgraduate Student

Email: npmendis@connect.ust.hk
Room: CYT2001

Pramuditha joined the Lakerveld Lab in August 2018. He completed his Bachelor's Degree in Chemical and Process Engineering at University of Moratuwa, Sri Lanka in 2017 with First Class Honors. He is a recipient of the prestigious HKPFS award from the Government of Hong Kong SAR, RGC. He is currently working in the area of continuous pharmaceutical crystallization. He enjoys walking, playing cricket, and listening to musing during his free time.

Dishika Gupta

Dishika Gupta

Postgraduate Student

Email: dguptaaa@connect.ust.hk
Room: CYT2007B

Dishika joined Lakerveld's lab in September 2019. She obtained her bachelor's degree from the department of chemical engineering of CBIT (Osmania University), India in 2018. She further graduated with a master's degree in chemical and biomolecular engineering from HKUST in 2019 and was awarded with an entrance scholarship from the university as a result of her meritorious background and internships. She is currently working on continuous anti-solvent crystallization of pharmaceuticals. In her spare time she enjoys watching movies, dancing and traveling.

Cheuk Hei Ho

Cheuk Hei (Matthew) Ho

Postgraduate Student

Email: chhoat@connect.ust.hk
Room: CYT2001

Matthew joined the Lakerveld Lab for an undergraduate research project in September 2017. After completing his bachelor’s degree in chemical engineering at HKUST, he continues his studies in the Lakerveld Lab as a postgraduate student and is now working on modelling of crystallization in emulsion. He passed ABRSM’s grade 8 piano exam with merit in 2018. He is a keyboard player who plays guitar and also a junkie of video games.

Alumni

Research

The core expertise of our research group is in the modeling, design, optimization, and control of chemical products and processes. In particular, we adopt unique computational and experimental approaches to improve the design and manufacture of self-assembled and crystalline materials. Furthermore, we have leveraged our expertise to improve environmental processes. Currently, our research finds applications in continuous (bio)pharmaceutical crystallization and self-assembly of colloidal systems and DNA nanostructures.

1. Control and optimization of directed self-assembly

Self-assembly is the spontaneous and reversible ordering of molecules or particles into small-scale structures. We speak of directed self-assembly when external forces are used to guide the self-assembly process. As a manufacturing technology of novel materials, self-assembly is exciting as it enables molecular precision and proceeds spontaneously. Self-assembly is driven by various interaction forces between particles and possibly by interaction of the particles with an external field. The key challenge for design and control is to engineer those interactions such that self-assembly proceeds in a desired direction. We are convinced that Process Systems Engineering as a field has much to contribute to develop systematic design approaches and control strategies for directed self-assembly. In particular, we are interested to solve what we call the "inverse problem" of directed self-assembly (Figure 1). To do so, we aim to develop optimization and automated control strategies to address this inverse problem for selected model systems.

inverse_problem_directed_self_assembly_illustration_Lakerveld

2. Continuous Pharmaceutical Crystallization

Pharmaceutical industry is a trillion dollar industry, which produces products that improve the quality of life of billions of people. The pharmaceutical industry is challenged by the need to develop improved manufacturing processes to obtain competitive advantages and deliver on modern-day demands related to the safety and environmental impact of their products and processes. Currently, there is a strong driver within industry to transform the way in which pharmaceuticals are being produced from batch-wise to continuous processing. Continuous manufacturing offers several exciting advantages to improve the sustainability, footprint, robustness, and efficiency of pharmaceutical manufacturing processes. Indeed, a full transition of the industry from batch-wise to continuous manufacturing may deliver similar benefits that have been enjoyed for decades by other branches within chemical industry and beyond. However, key organizational and technological challenges exist. In our group, we are generally interested in questions related to the design and control of continuous pharmaceutical processes. In particular, we investigate in detail pharmaceutical crystallization processes both with experiments and model-based simulations.

Publications

Journal publications (Google Scholar):

  1. Mathew Thomas, K.; Lakerveld, R. An Airlift Crystallizer for Protein Crystallization. Ind. Eng. Chem. Res. 2019, 58(44), 20381-20391.(link)
  2. Hadiwinoto, G.D.; Kwok, P.C.L.; Tong, H.H.Y.; Wong, S.N.; Chow, S.F.; Lakerveld, R. Integrated Continuous Plug-Flow Crystallization and Spray Drying of Pharmaceuticals for Dry Powder Inhalation. Ind. Eng. Chem. Res. 2019, 58(36), 16843-16857.(link)
  3. Gao, Y.; Lakerveld, R. Feedback Control for Shaping Density Distributions of Colloidal Particles in Microfluidic Devices. Lab Chip 2019, 19(13), 2168-2177. (link)(highlighted on the Inside front cover)
  4. Weng, J.; Wong, S.N.; Xu, X.; Xuan, B.; Wang, C.; Chen, R.; Sun, C.C.; Lakerveld, R.; Kwok, P.C.L.; Chow, S.F. Cocrystal Engineering of Itraconazole with Suberic acid via Rotary Evaporation and Spray Drying. Cryst. Growth. Des. 2019, 19(5), 2736-2745. (link)
  5. Gao, Y.; Lakerveld, R. Gain Scheduling PID Control for Directed Self-assembly of Colloidal Particles in Microfluidic Devices. AIChE J. 2019, 65, e16582. (link)
  6. Khodadadian, F.; De La Garza, F.G.; Van Ommen, J. R.; Stankiewicz, A. I.; Lakerveld, R. The Application of Automated Feedback and Feedforward Control to a LED-based Photocatalytic Reactor. Chem. Eng. J. 2019, 362, 375-382. (link)
  7. Gao, Y.; Lakerveld, R. Feedback Control for Defect-free Alignment of Colloidal Particles. Lab Chip 2018, 18, 2099-2110. (link)
  8. Li, F.; Lakerveld, R. Electric-field-assisted protein crystallization in continuous flow. Cryst. Growth Des. 2018, 18(5), 2964-2971. (link)
  9. Wang, J.; Fei, L.; Lakerveld, R. Process Intensification for Pharmaceutical Crystallization. Chem. Eng. Process. 2018, 127, 111-126. (link)(Invited - Special Issue on Process Intensification for Advanced Materials Synthesis)(among the most read papers of the journal for 12+ months)
  10. Nisar, M.; Sung, H.H.Y.; Puschmann, H.; Lakerveld, R.; Haynes, R.; Williams, I.D. 11-Azaartemisinin cocrystals with preserved lactam: acid heterosynthons. CrystEngComm 2018, 20(9), 1205-1219. (link)(Inside cover)
  11. Wang, J.; Lakerveld, R. Integrated Solvent and Process Design for Continuous Crystallization and Solvent Recycling using PC-SAFT. AIChE J. 2018, 64(4), 1205–1216. (link)
  12. Khodadadian, F.; De Boer, M.W.; Poursaeidesfahani, A.; Van Ommen, J. R.; Stankiewicz, A. I.; Lakerveld, R. Design, characterization and model validation of a LED-based photocatalytic reactor for gas phase applications. Chem. Eng. J. 2018, 333, 456-466. (link)
  13. Hadiwinoto, G.D.; Kwok*, P.C.L.; Lakerveld*, R. A review on recent technologies for the manufacture of pulmonary drugs. Ther. Deliv. 2017, 9(1), 47-70.(link)
  14. Li, F.; Lakerveld, R. The influence of alternating electric fields on protein crystallization in microfluidic devices with patterned electrodes in a parallel-plate configuration. Cryst. Growth Des. 2017, 17(6), 3062–3070. (link)
  15. Wang, J.; Lakerveld, R. Continuous Membrane-Assisted Crystallization to Increase the Attainable Product Quality of Pharmaceuticals and Design Space for Operation. Ind. Eng. Chem. Res. 2017, 56(19), 5705–5714.(link)
  16. Gao, Y.; Mi, Y.; Lakerveld, R. An optimization-based approach for structural design of self-assembled DNA tiles. AIChE J. 2017, 63(6), 1804-1817.(link)
  17. Mesbah, A.; Paulson, J.;Lakerveld, R.; Braatz, R.D. Model Predictive Control of an Integrated Continuous Pharmaceutical Manufacturing Pilot Plant. Org. Process Res. Dev. 2017, 21(6), 844–854. (link)
  18. Khodadadian, F.; Poursaeidesfahani, A.; Li, Z.; Van Ommen, J. R.; Stankiewicz, A. I.; Lakerveld, R. Model-based Optimization of a Photocatalytic Reactor with Light-Emitting Diodes. Chem. Eng. Technol. 2016, 39(10), 1946-1954. (link)
  19. Kacker, R.; Salvador, P.M.; Sturm, G.S.J.; Stefanidis, G.D.; Lakerveld, R.; Nagy, Z.K.; Kramer, H.J.M. Microwave Assisted Direct Nucleation Control for Batch Crystallization: Crystal Size Control with Reduced Batch Time. Cryst. Growth Des. 2016, 16(1), 440-446. (link)
  20. Ramaswamy, S.; Lakerveld, R.; Barton, P.I.; Stephanopoulos, G. Controlled Formation of Nanostructures with Desired Geometries: Part 3. Dynamic Modeling and Simulation of Directed Self-Assembly of Nanoparticles through Adaptive Finite State Projection. Ind. Eng. Chem. Res. 2015, 54(16), 4371-4384. (link)
  21. Lakerveld, R.; Benyahia, B.; Heider, P.L.; Zhang, H.; Wolfe, A.; Testa, C.J.; Ogden, S.; Hersey, D.R.; Mascia, S.; Evans, J.M.B.; Braatz, R.D.; Barton, P.I. The application of an automated control strategy for an integrated continuous pharmaceutical pilot plant. Org. Process Res. Dev. 2015, 19(9), 1088-1100. (link)
  22. Lakerveld, R.; Van Krochten, J.J.H.; Kramer, H.J.M. An air-lift crystallizer can suppress secondary nucleation at a higher supersaturation compared to a stirred crystallizer. Cryst. Growth Des. 2014 , 14(7), 3264-3275. (link)
  23. Lakerveld, R.; Sturm, G.S.J.; Stankiewicz, A.I.; Stefanidis, G.D. Integrated design of microwave and photocatalytic reactors. Where are we now? Curr. Opin. Chem. Eng. 2014 5,37-41. (link)
  24. Zhang, H.; Lakerveld, R.; Heider, P.L.; Tao, M.; Su, M.; Testa, C.; D'Antonio, A.; Barton, P.I.; Braatz, R.D.; Trout, B.L.; Myerson, A.S.; Jensen, K.F.; Evans, J.M.B. Application of continuous crystallization in an integrated continuous pharmaceutical pilot plant. Cryst. Growth Des.  2014, 14(5), 2148-2157. (link)
  25. Heider, P.L.; Born, S.C.; Basak, S.; Benyahia, B.; Lakerveld, R.; Zhang, H.; Hogan, R.; Buchbinder, L.; Wolfe, A.; Mascia, S.; Evans, J.M.B.; Jamison, T.F.; Jensen, K.F. Development of a Multi-Step Synthesis and Workup Sequence for an Integrated, Continuous Manufacturing Process of a Pharmaceutical. Org. Process Res. Dev. 2014, 18(3), 402-4093. (within the Top 20 of most read articles of February 2014 in OPRD) (link)
  26. Lakerveld, R.; Benyahia, B.; Heider, P.L., Zhang, H.; Braatz, R.D.; Barton, P.I. Averaging Level Control to Reduce Off-Spec Material in a Continuous Pharmaceutical Pilot Plant. Processes 2013, 1(3), 330–348. (Feature paper)(link)
  27. Mascia, S.; Heider, P.L.; Zhang, H.; Lakerveld, R.; Benyahia, B.; Barton, P.I.; Braatz, R.D.; Cooney, C.L.; Evans, J.M.B.; Jamison, T.F.; Jensen, K.F.; Myerson, A.S.; Trout, B.L. End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation. Angew. Chem. Int. Ed. 2013, 52(47), 12359-12363. ('Hot' paper, highlighted in Nature) (link)
  28. Lakerveld, R.; Benyahia, B.; Braatz, R.D.; Barton, P.I. Model-based design of a plant-wide control strategy for a continuous pharmaceutical plant. AIChE J. 2013, 59(10), 3671–3685. (link)
  29. Lakerveld, R.; Stephanopoulos, G.; Barton, P. I. A master-equation approach to simulate kinetic traps during directed self-assembly. Journal of Chemical Physics 2012, 136 (18). (link)
  30. Soare, A.; Lakerveld, R.; van Royen, J.; Zocchi, G.; Stankiewicz, A. I.; Kramer, H. J. M. Minimization of Attrition and Breakage in an Airlift Crystallizer. Industrial Engineering Chemistry Research. 2012, 51 (33), 10895-10909. (link)
  31. Benyahia, B.; Lakerveld, R.; Barton, P. I. A Plant-Wide Dynamic Model of a Continuous Pharmaceutical Process. Industrial Engineering Chemistry Research. 2012, 51 (47), 15393-15412. (link)
  32. Lakerveld, R.; Verzijden, N. G.; Kramer, H.; Jansens, P.; Grievink, J. Application of Ultrasound for Start-Up of Evaporative Batch Crystallization of Ammonium Sulfate in a 75-L Crystallizer. AIChE Journal 2011, 57 (12), 3367-3377. (link)
  33. Lakerveld, R.; Kramer, H. J. M.; Stankiewicz, A. I.; Grievink, J. Application of generic principles of process intensification to solution crystallization enabled by a task-based design approach. Chemical Engineering and Processing 2010, 49 (9), 979-991.(link)
  34. Lakerveld, R.; Kuhn, J.; Kramer, H. J. M.; Jansens, P. J.; Grievink, J. Membrane assisted crystallization using reverse osmosis: Influence of solubility characteristics on experimental application and energy saving potential. Chemical Engineering Science 2010, 65 (9), 2689-2699.(link)
  35. Lakerveld, R.; Kramer, H. J. M.; Jansens, P. J.; Grievink, J. The application of a task-based concept for the design of innovative industrial crystallizers. Computers & Chemical Engineering 2009, 33 (10), 1692-1700.(link)
  36. Kuhn, J.; Lakerveld, R.; Kramer, H. J. M.; Grievink, J.; Jansens, P. J. Characterization and Dynamic Optimization of Membrane-Assisted Crystallization of Adipic Acid. Industrial Engineering Chemistry Research. 2009, 48 (11), 5360-5369.(link)
  37. Lakerveld, R.; Bildea, C. S.; Almeida-Rivera, C. P. Exothermic isomerization reaction in a reactive flash: Steady-state behavior. Industrial Engineering Chemistry Research. 2005, 44 (10), 3815-3822.(link)

Book chapters:

  1. Lakerveld, R.; Benyahia, B. Process Control. Chapter 4. The Handbook of Continuous Crystallization (editors: Nima Yazdanpanah & Zoltan Nagy), Royal Society of Chemistry, 2020, ISBN: 978-1788012140, (forthcoming: 21 February 2020).
  2. Stelzer, T.; Lakerveld, R.; Myerson, A.S. Process Intensification in Continuous Crystallization. Chapter 10. The Handbook of Continuous Crystallization (editors: Nima Yazdanpanah & Zoltan Nagy), Royal Society of Chemistry, 2020, ISBN: 978-1788012140, (forthcoming: 21 February 2020).
  3. Kramer, H.J.M.; Lakerveld, R. Selection and design of industrial crystallizers. Chapter 7 in Handbook of Industrial Crystallization, 3rd edition, Cambridge University Press, 2019, ISBN: 9781139026949.
  4. Lakerveld, R.; Control system implementation and plant-wide control of continuous pharmaceutical manufacturing pilot plant (end-to-end manufacturing process). Chapter 16 in Process Systems Engineering for Pharmaceutical Manufacturing. Elsevier, 2018, ISBN: 978-0-444-63963-9.
  5. Lakerveld, R.; Heider, P. L.; Jensen, K. D.; Braatz, R. D.; Jensen, K. F.; Myerson, A. S.; Trout, B. L.; End-to-End Continuous Manufacturing: Integration of Unit Operations. Chapter 13 in Continuous Manufacturing of Pharmaceuticals. Wiley-Blackwell, 2017, ISBN: 978-1-119-00132-4.
  6. Khodadadian, F.; Nasalevich, M.; Kapteijn, F.; Stankiewicz, A.I.; Lakerveld, R.; Gascon, J. Photocatalysis: Past achievements and future trends. Chapter 8. RSC Green Chemistry. Volume 2016-January, Issue 47, 2016, Pages 227-269.

Invited lectures:

  1. Lakerveld, R. Industrial crystallization of Pharmaceuticals. East China University of Science and Technology, Shanghai, China, June 6, 2018.
  2. Lakerveld, R. Continuous Pharmaceutical Crystallization. 2018 International Forum on Crystal Engineering & Smart manufacturing (CESM2018), Tianjin, China, 2018.
  3. Lakerveld, R. Industrial crystallization of (bio)pharmaceuticals. Tianjin University and Hebei University of Technology, Tianjin, China, January 8, 2018.
  4. Lakerveld, R. Future directions in the manufacture of (bio)pharmaceuticals: continuous pharmaceutical crystallization and electric-field-assisted protein crystallization. Asian Dean's Forum Workshop on Bioengineering , NUS, Singapore, March 12, 2017.
  5. Lakerveld, R. Continuous Crystallization of Pharmaceuticals, Collaborative Conference on Crystal Growth, Hong Kong, December 14, 2015.
  6. Lakerveld, R.; Benyahia, B.; Heider, P.L.; Zhang, H.; Wolfe, A.; Testa, C.J.; Ogden, S.; D.R. Hersey; Mascia, S.; Evans, J.M.B.; Braatz, R.D.; Barton, P.I. The application of a plant-wide control strategy for an integrated continuous pharmaceutical pilot plant. SMi Quality by Design. London, UK, February 11, 2014.
  7. Lakerveld, R.; Benyahia, B.; Heider, P.L.; Zhang, H.; Mascia, S.; Evans, J.M.B.; Braatz, R.D.; Barton, P.I. A Plant-wide Control Strategy for an Integrated Continuous Pharmaceutical Pilot Plant. Pharma IQ’s 10th Annual PAT and Quality by Design Conference. London, UK, March 19, 2013.
  8. Lakerveld, R.; Benyahia, B.; Heider, P.L.; Zhang, H.; Mascia, S.; Evans, J.M.B.; Braatz, R.D.; Barton, P.I. The Application of a Plant-wide Control Strategy for a Continuous Pharmaceutical Process at the Novartis-MIT Center for Continuous Manufacturing. The University of Heidelberg International QbD / PAT Conference, Heidelberg, Germany, September 2012.
  9. Lakerveld, R.; Soare, A.; Kramer, H.J.M.; Stankiewicz, A.I. Opportunities for Process Intensification of Solution Crystallization. Japanese-Netherlands Conference on Crystal Growth, Sendai, Japan, July 2012.
  10. Lakerveld, R.; Evans, J.M.B.; Benyahia, B.; Braatz, R.D.; Barton, P.I. Implementing Continuous Manufacturing: The synergy between plant-wide control, modeling, and QbD. International Pharma QbD Forum, Berlin, Germany, April 2012.
  11. Lakerveld, R.; Kramer, H.J.M.; Jansens, P.J.; Grievink, J. Application of Task-Based Design for Solution Crystallization: Air Mixed Devices, Seeding, Ultrasound & Membranes. Group Users of Technology for Separation in the Netherlands (NLGUTS), Delft, The Netherlands, October 2009.
  12. Lakerveld, R. Kramer, H.J.M., Jansens, P.J. Grievink, J. Task Based Design Techniques for Solution Crystallization Processes. BASF Crystallization Symposium, Ludwigshafen, Germany, August 2008.
  13. Lakerveld, R., Kramer, H.J.M., Jansens, P.J., Grievink, J. Task Based Design Techniques for Solution Crystallization Processes. DSM Research & Technology, Geleen, The Netherlands, May 2008.

Selected papers in peer-reviewed conference proceedings:

  1. Gao, Y.; Lakerveld, R. Automated open-loop control of directed selfassembly with multiple electrokinetic actuators in microfluidic devices. Computer-Aided Chemical Engineering 46, 2019, 43–48.
  2. Nyande, B.W.; Gao, Y.; Lakerveld, R. A dynamic model for automated control of directed self-assembly of colloidal particles at low densities. Computer-Aided Chemical Engineering 46, 2019, 1783–1788.
  3. Gao, Y.; Lakerveld, R. Experimental Validation of Scheduled PID Control for Directed Self-Assembly of Colloidal Particles in Microfluidic Devices. Proceedings of the 13th International Symposium on Process Systems Engineering (PSE 2018), July 1 - July 4, 2018, San Diego, CA, USA, 2455–2460.
  4. Wang, J.; Lakerveld, R. Integrated Solvent and Process Optimization Using PC-SAFT for Continuous Crystallization with Energy-intensive Solvent Separation for Recycling. Proceedings of the 13th International Symposium on Process Systems Engineering (PSE 2018), July 1 - July 4, 2018, San Diego, CA, USA, 1051–1056.
  5. R. Lakerveld, B. Benyahia, P.L. Heider, H. Zhang, A. Wolfe, C.J. Testa, S. Ogden, D.R. Hersey, S. Mascia, J.M.B. Evans, R.D. Braatz, P.I. Barton, The Application of an Automated Plant-wide Control Strategy for a Continuous Pharmaceutical Pilot Plant. Proceedings of the 2014 American Control Conference, June 04-June 06, 2014, Portland, Oregon, USA, 3512-3517.
  6. R. Lakerveld, G. Stephanopoulos, P.I. Barton, Robust fabrication of non-periodic nanoscale systems via directed self-assembly. Computer-Aided Chemical Engineering 29, 2011, 1603-1607.
  7. R. Lakerveld, H.J.M. Kramer, P.J. Jansens, J. Grievink, The application of a task-based concept for design of innovative industrial crystallizers. PSE 2009 Conference Proceedings, Salvador, Brazil, 2009.
  8. R. Lakerveld, H.J.M. Kramer, A.I. Stankiewicz, P.J. Jansens, J. Grievink, Opportunities for process intensification in crystallization: application of air-mixed devices, ultrasound & membranes. EPIC 2009 Conference Proceedings, Venice, Italy, 2009.
  9. R. Lakerveld, H.J.M. Kramer, P.J. Jansens and J. Grievink, The Application of a Task Based Design Approach to Solution Crystallization. FOCAPD Conference Proceedings, Breckenridge, Colorado, United States, 2009.
  10. R. Lakerveld, H.J.M. Kramer, P.J. Jansens, J. Grievink, A task based design approach for solution crystallization. BIWIC 2008 Conference Proceedings, Magdeburg, Germany, 2008, 95-102.
  11. R. Lakerveld, H.J.M. Kramer, P.J. Jansens, J. Grievink, A Task Based Design Approach for Solution Crystallization. 17th International Symposium on Industrial Crystallization Conference Proceedings, Maastricht, The Netherlands, 2008, 27-34.
  12. R. Lakerveld, H.J.M. Kramer, P.J. Jansens, J. Grievink, Solution Crystallization in a Bubble Column. Optimization of the task: Crystal Growth, 17th International Symposium on Industrial Crystallization Conference Proceedings, Maastricht, The Netherlands, 2008, 819-826.
  13. R. Lakerveld, J. Kuhn, M.A. Bosch, H.J.M. Kramer, P.J. Jansens, J. Grievink,  Membrane Assisted Evaporative Crystallization: Optimization of Task Supersaturation Generation, 17th International Symposium on Industrial Crystallization Conference Proceedings, Maastricht, The Netherlands, 2008, 827-834.
  14. R. Lakerveld, P.G. Verzijden, H.J.M. Kramer, P.J. Jansens, J. Grievink, The Application of Ultrasound for Seeding Purposes Optimization of the task: Nucleation, 17th International Symposium on Industrial Crystallization Conference Proceedings, Maastricht, The Netherlands, 2008, 835-842.
  15. R. Lakerveld, H.J.M. Kramer, P.J. Jansens, J. Grievink, The application of a task-based concept for the design of innovative industrial crystallizers. 18th European Symposium on Computer Aided Process Engineering Conference Proceedings, Lyon, France 2008, 103-108.
  16. R. Lakerveld, A.N. Kalbasenka, H.J.M. Kramer, P.J. Jansens, J. Grievink, The application of different seeding techniques for solution crystallization of ammonium sulphate. BIWIC 2007 Conference Proceedings, Cape Town, South Africa, 2007, 221-228.
  17. R. Lakerveld, M.E. Djatmiko, H.J.M. Kramer, P.J. Jansens, J. Grievink, Task based design techniques for solution crystallisation processes: application to a bubble column setup. BIWIC 2006 Conference Proceedings, Delft, The Netherlands, 2006, 114 – 121.

Links:

News

  • Nov, 2019: Kiran's paper is among the most read articles from Industrial & Engineering Chemistry Research of the last 30 days. Congratulations!
  • Nov, 2019: Baggie, Kiran, and Richard present work of the group at the 2019 AIChE Annual Meeting in Orlando, Florida! Richard co-chairs a session on 3D printing.
  • Oct, 2019: Kiran's paper on protein crystallization in an airlift crystallizer has been published in Industrial & Engineering Chemistry Research. The airlift crystallizer can produce larger crystals with reduced attrition and also can deliver an increased throughput compared to a conventional stirred crystallizer for the studied model protein. The work also shows how 3D printing can be used to fabricate mini-pilot plant equipment rapidly and at low cost. Congratulations! (link)
  • Oct, 2019: Hongrui joins the lab as visiting exchange student from Tsinghua University. Welcome!
  • Sep, 2019: Richard has been elected a member of the 2019 Class of Influential Researchers of Industrial & Engineering Chemistry Research (see the editorial note and cover). Gabriela's paper (link) has been included in the corresponding special issue. Congratulations!
  • Sep, 2019: Richard has been awarded the School of Engineering Teaching Excellence Appreciation Award 2018-2019 (photo!). Congratulations!
  • Sep, 2019: UG students Sunny and Anshuman join the lab for an independent research project. Welcome!
  • Sep, 2019: MSc students Shiyu, Yao, Ziyang, and Rui join the lab for independent research projects. Welcome!
  • Sep, 2019: Postdoctoral associate Madiha joins the Lakerveld Lab. Welcome!
  • Sep, 2019: Postgraduate students Dishika and Matthew join the Lakerveld Lab. Welcome!
  • Sep, 2019: NPT magazine highlights this year's ESCAPE conference, which was co-organized by Richard and attended by Baggie. You can read the article here (e-mail registration required) with a photo of all participants enjoying the nice Dutch weather in early Summer.
  • Sep, 2019: Former MPhil student Junhao joins UC Irvine as a PhD student. Congratulations!
  • Aug, 2019: No less than four group members (a record!) have passed their PhD qualifying examination. Congratulations to Pramuditha, Soojin, Victor, and Xiaojin and good luck with the next phase as a PhD candidate!
  • Aug, 2019: Kiran has won a travel grant for the Next-Gen Manufacturing Topical Conference of the 2019 AIChE Annual Meeting in Orlando. The award is being provided kindly by the AIChE Foundation. Congratulations!
  • Aug, 2019: Gabriela's paper on integrated continuous crystallization and spray drying of pulmonary drugs has been published in Industrial & Engineering Chemistry Research. The collaborative work shows how continuous anti-solvent crystallization can produce crystals in the desired size range for dry powder inhalation in a single step followed by rapid solvent evapoation through spray drying. The novel process is demonstrated for two relevant pulmonary drugs. Congratulations! (link)
  • Jul, 2019: Junhao successfully defends his MPhil thesis. Congratulations!
  • Jul, 2019: The group has no less than 5 abstracts accepted for the 2019 AIChE Annual Meeting. Join us in Orlando to hear talks from Kiran, Baggie, and Richard on how to 3D-print innovative crystallization processes, how to used model-based control for directed self-assembly, or how to make pulmonary drugs in a single step without a need for conventional size-correction steps by using a compact and integrated continuous process! Richard will also co-chair a session with exciting talks on 3D printing within the broader topic of smart manufacturing.
  • Jul, 2019: The group has been awarded a GRF Research Grant from Hong Kong's University Grants Committee of HK$ 695,919 for investigating novel approaches to pharmaceutical crystallization for improved control over crystal size and product uniformity. Congratulations!
  • Jun, 2019: Yu's paper is featured on the Inside front cover of Lab on a Chip!
  • Jun, 2019: Baggie presents his research at the ESCAPE-29 conference in Eindhoven. Richard presents a key note lecture based on the work of Gao Yu. You can find the conference proceedings here, which have been co-edited by Richard.
  • Jun, 2019: Maryam successfully defends her PhD thesis at TU Delft. Congratulations!
  • Jun, 2019: The 3rd edition of the handbook of industrial crystallization edited by Allan S. Myerson (Massachusetts Institute of Technology), Deniz Erdemir (Bristol-Myers Squibb), and Alfred Y. Lee (Merck & Co., Inc) has been published including a chapter on the selection and design of industrial crystallizers written by Herman Kramer and Richard Lakerveld. link
  • May, 2019: Yu's paper on a novel automated control method to create specified density distribution of tiny particles in microfluidic devices based on directed self-assembly has been published in Lab on a Chip. Congratulations! The paper marks the latest contribution of a series of papers in which we show how concepts from process control can be combined with microfluidics to enable the defect-free fabrication of structured materials via attractive bottom-up synthesis approaches.(link)
  • May, 2019: Yi, Xiatong, Yue, Cong, Isaac, and Pasindu all successfully completed an individual research project in our group. Isaac wins the best poster award. Congratulations to all and good luck with future endeavors!
  • Apr, 2019: The Lakerveld lab (almost) complete a hiking trip to the highest peak of Hong Kong! The trip was followed by a well-deserved and authentic Korean dinner (as verified by two credible and qualified Lakerveld lab members). (photo).
  • Mar, 2019: A paper co-authored by Ruipeng and Richard on using evaporation and spray drying for cocrystal formation has been published in Crystal Growth and Design. Congratulations! (link)
  • Feb, 2019: Yu's paper on gain-scheduled feedback control applied to directed self-assembly of colloidal particles has been published in AIChE Journal. Congratulations! (link)
  • Feb, 2019: Richard co-guest-edited a special issue in the new journal Process Integration and Optimization for Sustainability (Springer) entitled "Process System Engineering for Sustainability in Asia Pacific". Our editorial note can be read here.
  • Jan, 2019: Yu's and Baggie's papers on automated control of directed self-assembly have been accepted for ESCAPE-29. Congratulations! Make sure to come to the always beautiful Netherlands (Spring time!) to see their work in the emerging theme of CAPE/PSE in hi-tech micro/nano-devices and processes. Richard will deliver the keynote lecture of the theme.
  • Jan, 2019: Jose joins the Lakerveld Lab as an international exchange student from University of Strathclyde, Glasgow. Welcome!
  • Dec, 2018: Maryam's paper presenting the first demonstration of how "smart" light sources can be combined with fast process analytical technologies in automated control loops for improved operation of a LED-based photocatalytic reactor has been accepted for publication in Chemical Engineering Journal. Congratulations! (link) (50 days free access via this link!)
  • Nov, 2018: Former PhD student Dr. Jiayuan Wang starts as a lecturer at Zhejiang University of Technology. Congratulations!
  • Nov, 2018: Former PhD student Dr. Yu Gao starts as a postdoctoral associate at The University of Colorado Boulder. Congratulations!.
  • Nov, 2018: Kiran presents his work at the AIChE Annual Meeting in Pittsburgh.
  • Sep, 2018: MSc students Yi, Xiatong, Yue, and Cong join the Lakerveld Lab for individual research projects. Welcome!
  • Sep, 2018: We have a vacancy for a postdoctoral associate (see vacancies). Submit your application and join us!
  • Aug, 2018: Baggie passes his PhD qualifying examination. Congratulations!
  • Aug, 2018: Jiayuan successfully defends his PhD thesis. Congratulations!
  • Aug, 2018: Postgraduate students Soojin, Xiaojin, and Pramuditha join the Lakerveld Lab. Welcome!
  • Aug, 2018: Former MPhil student and research assistant Gabriela joins the Professional Doctorate in Engineering (PDEng) traineeship at Delft University of Technology. Congratulations!
  • Aug, 2018: Jiayuan finishes his 2-month international exchange at the University of Strathclyde in Glasgow, Scotland.
  • Jul, 2018: Sherry successfully defends her MPhil thesis. Congratulations!
  • Jul, 2018: Yu and Jiayuan present their work at the 2018 PSE conference in San Diego, CA, USA!
  • Jul, 2018: The group has been awarded a GRF Research Grant from Hong Kong's University Grants Committee of HK$ 632,421 for investigating novel approaches to continuous pharmaceutical crystallization. Congratulations!
  • Jun, 2018: Postgraduate student Ruipeng joins the Lakerveld lab. Welcome!
  • Jun, 2018: The academic year has been officially closed with......a night of bowling followed by an authentic (as verified by a credible and qualified Lakerveld lab member) Indian dinner! Happy summer to everyone!
  • Jun, 2018: Yu's paper on automated feedback control for defect-free alignment of colloidal particles via directed self-assembly has been published in Lab on a Chip. Congratulations! (link)
  • Jun, 2018: Yu and Richard deliver invited lectures at the School of Chemical Engineering of the East China University of Science and Technology on control and optimization of directed self-assembly and pharmaceutical crystallization, respectively.
  • Jun, 2018: Jiayuan's and Fei's review paper on process intensification for pharmaceutical crystallization is among the most downloaded articles from Chemical Engineering and Processing - Process Intensification in the last 90 days. Congratulations!
  • Jun, 2018: Read our invited article on pharmaceutical crystallization in Issue 31 of Pharma Focus Asia, a leading pharma magazine in print and digital versions across Asia and rest of the world.
  • May, 2018: Andrew successfully finishes his 6-month international exchange and is heading back to Tsinghua University, Beijing. Thanks Andrew and good luck wrapping up your studies!
  • May, 2018: Richard chairs a session and delivers an invited plenary speech at the 2018 International Forum on Crystal Engineering & Smart manufacturing (CESM2018) in Tianjin.
  • May, 2018: Nicole, Jonathan, Kay, Isaac and Matthew all successfully present the results of their individual undergraduate research project in the Lakerveld Lab to CBE faculty. Congratulations and job well done!
  • Apr, 2018: Fei's paper on electric-field-assisted protein crystallization in continuous flow has been accepted for publication in Crystal Growth & Design. Congratulations! (link)
  • Mar, 2018: Jiayuan's and Fei's review paper on process intensification for pharmaceutical crystallization has been accepted for publication in Chemical Engineering Processing: Process Intensification. Congratulations!(link)
  • Feb, 2018: Yu and Jiayuan have papers accepted for the PSE 2018 conference. Come to San Diego to see their work on automated control of directed self-assembly and integrated process and solvent design for continuous pharmaceutical crystallization!
  • Feb, 2018: Former postdoc Dr. Fei Li accepts a faculty position at Tianjin University. Congratulations!
  • Jan, 2018: The Lakerveld lab complete a hiking trip followed by a well-deserved dinner in Lamma Island (photo).
  • Jan, 2018: Gao Yu successfully defends his PhD thesis. Congratulations!
  • Jan, 2018: A paper co-authored by Richard on 11-Azaartemisinin cocrystals has appeared in CrystEngComm. You can find our paper here.
  • Jan, 2018: Richard delivers invited lectures on industrial crystallization of (bio)pharmaceuticals at Tianjin University and Hebei University of Technology.
  • Dec, 2017: Andrew joins the Lakerveld lab from Tsinghua University Beijing as an exchange postgraduate student for 6 months. Welcome!
  • Oct, 2017: Gabriela's review paper on recent technologies for the manufacture of pulmonary drugs has been accepted for publication in Therapeutic Delivery. Congratulations!(link)
  • Oct, 2017: Jiayuan's paper on integrated solvent and process design for continuous crystallization and solvent Recycling using PC-SAFT has been accepted for publication in AIChE Journal. Congratulations!(link)
  • Sep, 2017: Maryam's paper on the design, characterization and model validation of a LED-based photocatalytic reactor for gas phase applications has been accepted for publication in Chemical Engineering Journal. Congratulations!(link)
  • Sep, 2017: MSc student Jintao joins the Lakerveld Lab for an individual research project. Welcome!
  • Sep, 2017: Undergraduate students Nicole, Isaac, and Matthew join the Lakerveld Lab for individual research projects. Welcome!
  • Aug, 2017: Fei, Yu, Jiayuan, and Gabriela present their work at the 17th Congress of the Asian Pacific Confederation of Chemical Engineering (APCChE2017).
  • Aug, 2017: Postgraduate students Baggie and Junhao join the Lakerveld lab. Welcome!
  • Aug, 2017: A book chapter co-authored by Richard on integrated continuous pharmaceutical manufacturing has been published by Wiley. Congratulations!
  • Jul, 2017: The academic year has been officially closed with a delicious summer BBQ (photo)!
  • Jul, 2017: Gabriela successfully defends her MPhil thesis on a novel continuous crystallization process for pulmonary drugs. Congratulations!
  • Jul, 2017: The group has been awarded a GRF Research Grant from Hong Kong's University Grants Committee of HK$ 582,000 for investigating novel methods for automated control of directed self-assembly processes. Congratulations!
  • May, 2017: A paper co-authored by Richard and co-workers from MIT and UC Berkeley on model predictive control of an integrated continuous pharmaceutical manufacturing pilot plant has appeared in Organic Process Research & Development. You can find our paper here.
  • May, 2017: Fei's paper on electric-field-assisted protein crystallization has been accepted for publication in Crystal Growth & Design. Congratulations! (link)
  • Apr, 2017: Jiayuan's paper on continuous membrane-assisted crystallization to increase the attainable product quality of pharmaceuticals and design space for operation has been accepted for publication in Industrial & Engineering Chemistry Research. Congratulations! (link)
  • Apr, 2017: Gabriela and Jiayuan have abstracts accepted for the ISIC conference in Dublin, Ireland. Come to Ireland to learn more about their work on continuous pharmaceutical crystallization!
  • Mar, 2017: Richard and collaborators receive an ITF Tier 3 Grant of HK$1,400,000 to investigate integrated continuous pharmaceutical manufacturing of a drug application. Co-investigators are Prof. Philip C.L. Kwok (The University of Hong Kong) and Prof. Henry H.Y. Tong (Macao Polytechnic Institute). Congratulations!
  • Mar, 2017: Richard delivers an invited lecture on "Future directions in the manufacture of (bio)pharmaceuticals: continuous pharmaceutical crystallization and electric-field-assisted protein crystallization" at the Asian Dean's Forum Workshop on Bioengineering at NUS in Singapore.
  • Nov, 2016: Fei and Yu present their work at the AIChE Annual Meeting in San Francisco.
  • Nov, 2016: The Lakerveld lab complete a hiking trip followed by a well-deserved dinner in Sai Kung.
  • Oct, 2016: Yu's paper presenting an optimization-based approach for structural design of self-assembled DNA tiles has been accepted for publication in AIChE Journal. Congratulations! (link)
  • Sep, 2016: Maryam's book chapter on the past achievements and future trends of photocatalysis has been published by the Royal Society of Chemistry. Congratulations!
  • Sep, 2016: Kay and Monalisa join the Lakerveld lab for individual research projects. Welcome!
  • Aug, 2015: Postgraduate student Xiao Hua joins the Lakerveld lab. Welcome!
  • Aug, 2015: Postgraduate student Kiran Mathew Thomas joins the Lakerveld lab. Welcome!
  • Aug, 2016: Jonathan presents the results of his undergraduate research project on control of directed self-assembly to CBME faculty and successfully finishes his project. Congratulations!
  • Aug, 2016: Yoshine successfully finishes her summer International Research Opportunities Program (IROP) project on modeling and optimization of continuous pharmaceutical crystallization. Congratulations!
  • Jul, 2016: The academic year has been officially closed with a delicious summer BBQ (photo)!
  • Jul, 2016: Yu and Fei have abstracts accepted for oral presentations at the 2016 AIChE Annual Meeting in San Francisco. Come see their talks to learn more about electric-field-assisted protein crystallization, a novel optimization-based method for structural design of self-assembled DNA tiles, or an experimental validation of novel open-loop control methods for directed self-assembly!
  • Jul, 2016: The group has been awarded a GRF Research Grant from Hong Kong's University Grants Committee of HK$ 675,647 for investigating novel methods to improve control over protein crystallization. Congratulations!
  • Jun, 2016: Yoshine joins the Lakerveld lab from MIT for a summer International Research Opportunities Program (IROP). Welcome!
  • Jun, 2016: Maria joins the Lakerveld lab from University of Indonesia for an International Summer Internship. Welcome!
  • Jun, 2016: Maryam's paper on the model-based optimization of a photocatalytic reactor with light-emitting diodes has been accepted for publication in Chemical Engineering & Technology. Congratulations! (link)
  • May, 2016: Mickey and Aaron successfully finalized their individual undergraduate research project. Congratulations!
  • Apr, 2016: The Lakerveld lab conquers the Clear Water Bay Country Park with a 3-hour hiking session!
  • Jan, 2016: Winnie, Jonathan, and Varun join the Lakerveld Lab for individual undergraduate research projects on continuous pharmaceutical crystallization and directed self-assembly. Welcome!
  • Dec, 2015: Richard delivers an invited lecture on continuous crystallization of pharmaceuticals at the 2015 Collaborative Conference on Crystal Growth in Hong Kong.
  • Dec, 2015: A paper co-authored by Richard and co-workers from Purdue, TU Delft, and KU Leuven on a novel automated method to rapidly dissolve small crystals using microwaves during batch pharmaceutical crystallization has appeared in Crystal Growth and Design. You can find our paper here.
  • Nov, 2015: The Lakerveld lab celebrates its one-year anniversary with a BBQ at the sea front. Congratulations to Yu Gao for bringing into practice one of the newly launched HKUST official core values by managing to put 8 pieces of meat on a single stick ("Can-do Spirit")!
  • Nov, 2015: Maryam presents her work at the 2015 AIChE Annual Meeting in Salt Lake City (USA) and at the 21st AOTs in San Diego (USA).
  • Sep, 2015: Maryam presents her work at the 10th European Congress of Chemical Engineering in Nice (France).
  • Sep, 2015: Aaron and Mickey join the Lakerveld Lab for an undergraduate research project on continuous pharmaceutical crystallization. Welcome!
  • Sep, 2015: A paper authored by Richard and co-workers from MIT on the automated plant-wide control of the world's first fully integrated continuous pharmaceutical pilot plant has appeared in a special issue of Organic Process Research Development. The special issue features innovative ideas and technologies to address challenges in chemical and pharmaceutical development. You can read the introduction to the special issue here and find our paper here.
  • Aug, 2015: The Lakerveld Lab moves into their new home: a brand new office and laboratory space!
  • Aug, 2015: Postgraduate student Gabriela Hadiwinoto joins the Lakerveld lab. Welcome!
  • Aug, 2015: Postgraduate student Jiayuan Wang joins the Lakerveld lab. Welcome!
  • Jul, 2015: Richard has been awarded Outstanding Reviewer Status by Elsevier for his reviews completed for Chemical Engineering & Processing: Process Intensification in the past two years
  • May, 2015: Maryam's abstract has been accepted for presentation at the ECCE10-ECAB3-EPIC5 to be held in Nice in September. Congratulations!
  • Apr, 2015: Dr. Fei Li joins the Lakerveld lab as a Postdoctoral Associate. Welcome!
  • Feb, 2015: A paper co-authored by Richard and co-workers from MIT on the dynamic modeling of directed self-assembly via a novel adaptive finite state projection appears online in Industrial & Engineering Chemistry Research.(link)
  • Jan, 2015: A paper co-authored by Richard and co-workers from MIT and Berkeley on plant-wide model predictive control of a continuous pharmaceutical process has been accepted for an oral presentation at the 2015 American Control Conference. A pre-print of the paper can be found here.
  • Dec, 2014: Richard receives the Novartis-MIT Enabling Control System Award for his contribution to the first end-to-end integrated continuous pharmaceutical pilot plant (...and since it has been crafted very beautifully, have a look at the photo!).
  • Oct, 2014: Postgraduate student Gao Yu joins the Lakerveld lab. Welcome!
  • Oct, 2014: Richard Lakerveld joins the CBE department of Hong Kong University of Science and Technology as an Assistant Professor.
  • Vacancies

    Postdoctoral Associate

    We currently have no vacancies for Postdoctoral Associates in our group. Nevertheless, please feel free to submit your CV if you are highly motivated and well qualified. We will keep you CV on file in case openings would become available in the future. Please also contact Prof. Lakerveld if you have your own funding or are considering to apply for funding to support a position as postdoctoral associate in our group, for example through the national science foundation of your home country.

    Postgraduate Students

    Vacancies for fully funded postgraduate positions are available (PhD or MPhil)! If you have shown academic excellence at a reputable university, are highly motivated, and you have an interest in Chemical Engineering in general, and in the research of our group in particular, please contact Prof. Lakerveld directly for enquiries. Please use an institutional email address if possible to avoid that your email will be flagged as junk email automatically.

    HKUST is a modern, English-speaking, top-ranked University in Asia. HKUST’s School of Engineering consistently ranks among the top 25 programs in the world. Prof. Lakerveld’s research interests are in the field of Process Systems Engineering. In particular, the focus of the group is on the design and control of processes that involve the production of structured materials. Such processes are typically driven by crystallization or directed self-assembly. Research interests span from controlled assembly of individual building blocks into specific structures on a small scale to optimal integration of unit operations into continuous pharmaceutical manufacturing systems on a large scale.

    Candidates should have a BEng or MSc degree (or equivalent) in chemical engineering or related discipline. Sufficient proficiency in the English language is required as demonstrated by an internationally recognized English test score. Extracurricular activities and international exposure are appreciated.

    Outstanding applicants will be considered for the highly generous and prestigious Hong Kong PhD Fellowship Scheme (current stipend of HK$25,800/month plus additional awards and travel allowances). Please see the following link for details on the HKPFS or please contact Prof. Lakerveld for enquiries.

    Contact

    HKUST campus

    Richard Lakerveld
    The Hong Kong University of Science and Technology
    Department of Chemical and Biological Engineering
    Clear Water Bay, Kowloon, Hong Kong
    Email: r.lakerveld@ust.hk
    Room: CYT2003 (lift 35/36)
    Phone: (852) 3469 2217

    Please see Maps and Directions for more details on campus accessibility