Welcome!

Our group investigates the design and manufacture of self-assembled and crystalline materials using innovative approaches for process control, integration, and model-based optimization. Typical applications involve high value-added products such as pharmaceuticals and advanced materials that are functionalized by tiny structural features. Our approach is both computational and experimental. The former typically includes model-based design and optimization studies whereas the latter involves experimental validation of novel concepts for process design, integration, and control.

Meet our group members, read more about our research, have a look at our publications, read the news, or join us!

People

Richard Lakerveld

Richard Lakerveld

Principal Investigator

Email: kelakerveld@ust.hk
Room: CYT2003
Phone: (852) 3469 2217
Faculty page

Richard Lakerveld is an Assistant Professor in the Department of Chemical and Biological Engineering (CBE) at The Hong Kong University of Science and Technology (HKUST). Furthermore, he is an Honorary Assistant Professor in the Department of Pharmacology and Pharmacy at The University of Hong Kong (HKU). He joined the CBE department of HKUST in October 2014. He was an Assistant Professor at Delft University of Technology for 2 years before joining the faculty of HKUST. Prior to that, he worked for 2 years as Postdoctoral Associate at the Process Systems Engineering Laboratory of the Massachusetts Institute of Technology in the group of Paul Barton. At MIT, he worked on plant-wide control of continuous pharmaceutical manufacturing and on optimal control of directed self-assembly. He received his chemical engineering education from Delft University of Technology where he obtained both his MSc and PhD degree cum laude. His PhD research involved the development of a task-based design approach for solution crystallization processes under supervision of Johan Grievink, Peter Jansens, and Herman Kramer. He completed an Honors Track at TUD and was an exchange graduate student at HKUST in 2009. Furthermore, he was the recipient of an NWO Veni Award in 2013, which is an early career award from the Dutch Science Foundation. His other personal awards include a VNCI award, the Novartis-MIT Enabling Control System Award, and three consecutive GRF Awards from Hong Kong's Science Foundation, which are personal grants aimed at supporting cutting-edge research. His research interests are in the field of Process Systems Engineering with a focus on the control and optimization of the design and the manufacture of crystalline and self-assembled materials. When time permits, he likes to take his bike for a road trip or spend some time on the football pitch.

Kiran Mathew Thomas

Kiran Mathew Thomas

Postgraduate Student

Email: kiran.mathew.thomas@connect.ust.hk
Room: CYT2007B

Kiran joined the Lakerveld Lab in August 2016. He graduated from VIT University, India, in 2012 with a Bachelor degree in Mechanical Engineering. He obtained his MSc degree in Process and Energy Engineering in 2014 from Delft University of Technology, The Netherlands. He held several internship position in Process and Energy companies around the world and his MSc graduation research work has been published in a prestigious academic journal. He is currently working on new experimental concepts for continuous pharmaceutical crystallization. In his leisure time, he enjoys travelling and solving puzzles.

Po Sang Lo

Po Sang (Victor) Lo

Postgraduate Student

Email: pslo@connect.ust.hk
Room: CYT2007B

Victor joined the Lakerveld Lab in December 2016. He graduated from The Hong Kong University of Science and Technology in 2016 with a Bachelor degree in Chemical and Biomolecular Engineering. He joined the HKUST Student Court, studied in the USA, participated in cultural exchange programs in China, took part in undergraduate research programs at HKUST and won prizes in three regional and national research project competitions. He is also the member of both American Chemical Society and American Institute of Chemical Engineers. He is currently working on the continuous pharmaceutical crystallization. In his leisure time, he enjoys participating volunteer works, and travelling.

Baggie Waponde Nyande

Baggie Waponde Nyande

Postgraduate Student

Email: bwnyande@connect.ust.hk
Room: CYT2001

Baggie joined the Lakerveld Lab in September 2017. He graduated from the Department of Chemical and Materials Engineering at the Kwame Nkrumah University of Science and Technology in Ghana in 2014 with first-class honors. After his undergraduate studies, he obtained an Master degree from the Department of Chemical and Biological Engineering at Hanbat National University in Korea at the top of his class. He is the recipient of the prestigious HKPFS award from the Hong Kong government to attract top-notch postgraduate students to Hong Kong. He is working on automated control of directed self-assembly processes. In his spare time, he likes to play football and reading about geopolitics.

Junhao Gu

Junhao Gu

Postgraduate Student

Email: jguae@connect.ust.hk
Room: CYT2001

Junhao joined the Lakerveld Lab in September 2017. He graduated from The University of Toronto in 2016 with a Bachelor degree with a major in Chemical Engineering and a minor in Bioengineering. He was on the Dean's list for three years in a row and co-authored a paper in PNAS. He is working on directed self-assembly of cells. In his leisure time, he likes swimming and badminton and has broader academic interests in programming and machine learning related topics.

Ruipeng Chen

Ruipeng Chen

Postgraduate Student

Email: rchenar@connect.ust.hk
Room: CYT2007B

Ruipeng Joined the Lakerveld group in June 2018. He graduated from Tongji University in 2013 with a bachelor degree in applied chemistry, he obtained several scholarships and student union awards, ranking 5% in his deparment, for which he was admitted as a master student of Tongji University without the entrance exam. He completed his master degree in 2016 and his master thesis focus on the self-asembly of DNA origami. He is currently working on protein crystallization in continuous flow. In his spare time, he likes to play basketball and watch science fiction movies. He's a big fan of the Houston Rockets of NBA.

Xiaojin Xu

Xiaojin Xu

Postgraduate Student

Email: xxuan@connect.ust.hk
Room: CYT2001

Xiaojin joined the Lakerveld Lab in September 2018. He graduated from Sun Yat-Sen University in 2016 with a Bachelor degree in Chemical Engineering and Technology. Afterwards, he obtained his Master degree from the Department of Chemical and Biological Engineering in HKUST in early 2018. During his Msc studies, he received an Excellent Student Scholarship and participated in a research internship programme related to molecular dynamics in Spanish National Research Council for 6 months. He is currently working on design and optimization of DNA self-assembly. In his leisure time, he enjoys watching movies and travelling around.

Soojin Kwon

Soojin Kwon

Postgraduate student

Email: sjkwon@connect.ust.hk
Room: CYT2007B

Soojin joined the Lakerveld Lab in August 2018. She obtained both BSc and MSc in Chemical Engineering from Inha University, South Korea in 2016 and 2018, respectively. She ranked the first in her department when she graduated from undergraduate school and received academic scholarships during her studies. Her MSc works involved development of mathematical model for process system such as membrane, reactor, etc. She is currently working on continuous pharmaceutical process intensification. In spare time, she enjoys running, riding her bike and other sports.

Pramuditha Mendis

Nethrue Pramuditha Mendis

Postgraduate Student

Email: npmendis@connect.ust.hk
Room: CYT2001

Pramuditha joined the Lakerveld Lab in August 2018. He completed his Bachelor's Degree in Chemical and Process Engineering at University of Moratuwa, Sri Lanka in 2017 with First Class Honors. He is a recipient of the prestigious HKPFS award from the Government of Hong Kong SAR, RGC. He is currently working in the area of continuous pharmaceutical crystallization. He enjoys walking, playing cricket, and listening to musing during his free time.

Gao Yu

Fatemeh (Maryam) Khodadadian

Postgraduate Student

Email: F.Khodadadian@tudelft.nl
Address:
Process and Energy Department
Delft University of Technology
The Netherlands

Maryam received her bachelor degree in chemical engineering in 2007 in Iran. Her Master Thesis was about the effect of cerium and phosphorous loadings on HZSM-5 zeolite performance in hydrocracking of Naphtha. She graduated in 2011 as the first ranked student from Tarbiat Modares University in Iran. In September 2012, she joined the intensified reaction and separation system (IRS) group in the Process and Energy Department of TU Delft. Her current research involves modeling and optimization of LED-based photocatalytic reactors. She is located at Delft University in the Netherlands and jointly supervised by Richard, Andrzej Stankiewicz (TUD) and Ruud van Ommen (TUD). In spare time, she enjoys swimming, painting, reading classic novels and watching movies.

Alumni

Research

Broadly speaking our research aims to improve the design and control of processes that involve the production of high-added-value materials. The functionality of such materials often relies on a specific composition (e.g., in the case of pharmaceuticals) and on a specific structure (e.g., crystalline or self-assembled materials) with stringent specifications for product quality. We are interested in the design and control of the processes to make those materials. Such processes are often driven by crystallization or directed self-assembly and can be found in a wide variety of industries such as fine-chemicals, pharmaceutical, and high-tech industries. Research interests span from controlled assembly of individual building blocks into specific structures on a small scale to optimal integration of unit operations into continuous manufacturing systems on a large scale. Our research approach is both computational (e.g., dynamic large-scale modelling, optimization) and experimental (e.g., analysing tiny replicas of processes). In particular, our current research proceeds along two lines as described in more detail below.

1. Control and optimization of directed self-assembly

Self-assembly is the spontaneous and reversible ordering of molecules or particles into small-scale structures. We speak of directed self-assembly when external forces are used to guide the self-assembly process. As a manufacturing technology of novel materials, self-assembly is exciting as it enables molecular precision and proceeds spontaneously. Self-assembly is driven by various interaction forces between particles and possibly by interaction of the particles with an external field. The key challenge for design and control is to engineer those interactions such that self-assembly proceeds in a desired direction. We are convinced that Process Systems Engineering as a field has much to contribute to develop systematic design approaches and control strategies for directed self-assembly. In particular, we are interested to solve what we call the "inverse problem" of directed self-assembly (Figure 1). To do so, we aim to develop optimization and automated control strategies to address this inverse problem for selected model systems.

inverse_problem_directed_self_assembly_illustration_Lakerveld

2. Continuous Pharmaceutical Crystallization

Pharmaceutical industry is a multi-billion dollar industry, which produces products that improve the quality of life of billions of people. The pharmaceutical industry is challenged by the need to develop improved manufacturing processes to obtain competitive advantages and deliver on modern-day demands related to the safety and environmental impact of their products and processes. Currently, there is a strong driver within industry to transform the way in which pharmaceuticals are being produced from batch-wise to continuous processing. Continuous manufacturing offers several exciting advantages to improve the sustainability, footprint, robustness, and efficiency of pharmaceutical manufacturing processes. Indeed, a full transition of the industry from batch-wise to continuous manufacturing may deliver similar benefits that have been enjoyed for decades by other branches within chemical industry and beyond. However, key organizational and technological challenges exist. In our group, we are generally interested in questions related to the design and control of continuous pharmaceutical processes. In particular, we investigate in detail pharmaceutical crystallization processes both with experiments and model-based simulations.

Publications

Journal publications (Google Scholar):

  1. Gao, Y.; Lakerveld, R. Feedback Control for Defect-free Alignment of Colloidal Particles. Lab Chip 2018, 18, 2099-2110. (link)
  2. Li, F.; Lakerveld, R. Electric-field-assisted protein crystallization in continuous flow. Cryst. Growth Des. 2018, 18(5), 2964-2971. (link)
  3. Wang, J.; Fei, L.; Lakerveld, R. Process Intensification for Pharmaceutical Crystallization. Chem. Eng. Process. 2018, 127, 111-126. (link)(Invited - Special Issue on Process Intensification for Advanced Materials Synthesis)
  4. Nisar, M.; Sung, H.H.Y.; Puschmann, H.; Lakerveld, R.; Haynes, R.; Williams, I.D. 11-Azaartemisinin cocrystals with preserved lactam: acid heterosynthons. CrystEngComm 2018, 20(9), 1205-1219. (link)(Inside cover)
  5. Wang, J.; Lakerveld, R. Integrated Solvent and Process Design for Continuous Crystallization and Solvent Recycling using PC-SAFT. AIChE J. 2018, 64(4), 1205–1216. (link)
  6. Khodadadian, F.; De Boer, M.W.; Poursaeidesfahani, A.; Van Ommen, J. R.; Stankiewicz, A. I.; Lakerveld, R. Design, characterization and model validation of a LED-based photocatalytic reactor for gas phase applications. Chem. Eng. J. 2018, 333, 456-466. (link)
  7. Hadiwinoto, G.D.; Kwok*, P.C.L.; Lakerveld*, R. A review on recent technologies for the manufacture of pulmonary drugs. Ther. Deliv. 2017, 9(1), 47-70.(link)
  8. Li, F.; Lakerveld, R. The influence of alternating electric fields on protein crystallization in microfluidic devices with patterned electrodes in a parallel-plate configuration. Cryst. Growth Des. 2017, 17(6), 3062–3070. (link)
  9. Wang, J.; Lakerveld, R. Continuous Membrane-Assisted Crystallization to Increase the Attainable Product Quality of Pharmaceuticals and Design Space for Operation. Ind. Eng. Chem. Res. 2017, 56(19), 5705–5714.(link)
  10. Gao, Y.; Mi, Y.; Lakerveld, R. An optimization-based approach for structural design of self-assembled DNA tiles. AIChE J. 2017, 63(6), 1804-1817.(link)
  11. Mesbah, A.; Paulson, J.;Lakerveld, R.; Braatz, R.D. Model Predictive Control of an Integrated Continuous Pharmaceutical Manufacturing Pilot Plant. Org. Process Res. Dev. 2017, 21(6), 844–854. (link)
  12. Khodadadian, F.; Poursaeidesfahani, A.; Li, Z.; Van Ommen, J. R.; Stankiewicz, A. I.; Lakerveld, R. Model-based Optimization of a Photocatalytic Reactor with Light-Emitting Diodes. Chem. Eng. Technol. 2016, 39(10), 1946-1954. (link)
  13. Kacker, R.; Salvador, P.M.; Sturm, G.S.J.; Stefanidis, G.D.; Lakerveld, R.; Nagy, Z.K.; Kramer, H.J.M. Microwave Assisted Direct Nucleation Control for Batch Crystallization: Crystal Size Control with Reduced Batch Time. Cryst. Growth Des. 2016, 16(1), 440-446. (link)
  14. Ramaswamy, S.; Lakerveld, R.; Barton, P.I.; Stephanopoulos, G. Controlled Formation of Nanostructures with Desired Geometries: Part 3. Dynamic Modeling and Simulation of Directed Self-Assembly of Nanoparticles through Adaptive Finite State Projection. Ind. Eng. Chem. Res. 2015, 54(16), 4371-4384. (link)
  15. Lakerveld, R.; Benyahia, B.; Heider, P.L.; Zhang, H.; Wolfe, A.; Testa, C.J.; Ogden, S.; Hersey, D.R.; Mascia, S.; Evans, J.M.B.; Braatz, R.D.; Barton, P.I. The application of an automated control strategy for an integrated continuous pharmaceutical pilot plant. Org. Process Res. Dev. 2015, 19(9), 1088-1100. (link)
  16. Lakerveld, R.; Van Krochten, J.J.H.; Kramer, H.J.M. An air-lift crystallizer can suppress secondary nucleation at a higher supersaturation compared to a stirred crystallizer. Cryst. Growth Des. 2014 , 14(7), 3264-3275. (link)
  17. Lakerveld, R.; Sturm, G.S.J.; Stankiewicz, A.I.; Stefanidis, G.D. Integrated design of microwave and photocatalytic reactors. Where are we now? Curr. Opin. Chem. Eng. 2014 5,37-41. (link)
  18. Zhang, H.; Lakerveld, R.; Heider, P.L.; Tao, M.; Su, M.; Testa, C.; D'Antonio, A.; Barton, P.I.; Braatz, R.D.; Trout, B.L.; Myerson, A.S.; Jensen, K.F.; Evans, J.M.B. Application of continuous crystallization in an integrated continuous pharmaceutical pilot plant. Cryst. Growth Des.  2014, 14(5), 2148-2157. (link)
  19. Heider, P.L.; Born, S.C.; Basak, S.; Benyahia, B.; Lakerveld, R.; Zhang, H.; Hogan, R.; Buchbinder, L.; Wolfe, A.; Mascia, S.; Evans, J.M.B.; Jamison, T.F.; Jensen, K.F. Development of a Multi-Step Synthesis and Workup Sequence for an Integrated, Continuous Manufacturing Process of a Pharmaceutical. Org. Process Res. Dev. 2014, 18(3), 402-4093. (within the Top 20 of most read articles of February 2014 in OPRD) (link)
  20. Lakerveld, R.; Benyahia, B.; Heider, P.L., Zhang, H.; Braatz, R.D.; Barton, P.I. Averaging Level Control to Reduce Off-Spec Material in a Continuous Pharmaceutical Pilot Plant. Processes 2013, 1(3), 330–348. (Feature paper)(link)
  21. Mascia, S.; Heider, P.L.; Zhang, H.; Lakerveld, R.; Benyahia, B.; Barton, P.I.; Braatz, R.D.; Cooney, C.L.; Evans, J.M.B.; Jamison, T.F.; Jensen, K.F.; Myerson, A.S.; Trout, B.L. End-to-End Continuous Manufacturing of Pharmaceuticals: Integrated Synthesis, Purification, and Final Dosage Formation. Angew. Chem. Int. Ed. 2013, 52(47), 12359-12363. ('Hot' paper, highlighted in Nature) (link)
  22. Lakerveld, R.; Benyahia, B.; Braatz, R.D.; Barton, P.I. Model-based design of a plant-wide control strategy for a continuous pharmaceutical plant. AIChE J. 2013, 59(10), 3671–3685. (link)
  23. Lakerveld, R.; Stephanopoulos, G.; Barton, P. I. A master-equation approach to simulate kinetic traps during directed self-assembly. Journal of Chemical Physics 2012, 136 (18). (link)
  24. Soare, A.; Lakerveld, R.; van Royen, J.; Zocchi, G.; Stankiewicz, A. I.; Kramer, H. J. M. Minimization of Attrition and Breakage in an Airlift Crystallizer. Industrial Engineering Chemistry Research. 2012, 51 (33), 10895-10909. (link)
  25. Benyahia, B.; Lakerveld, R.; Barton, P. I. A Plant-Wide Dynamic Model of a Continuous Pharmaceutical Process. Industrial Engineering Chemistry Research. 2012, 51 (47), 15393-15412. (link)
  26. Lakerveld, R.; Verzijden, N. G.; Kramer, H.; Jansens, P.; Grievink, J. Application of Ultrasound for Start-Up of Evaporative Batch Crystallization of Ammonium Sulfate in a 75-L Crystallizer. AIChE Journal 2011, 57 (12), 3367-3377. (link)
  27. Lakerveld, R.; Kramer, H. J. M.; Stankiewicz, A. I.; Grievink, J. Application of generic principles of process intensification to solution crystallization enabled by a task-based design approach. Chemical Engineering and Processing 2010, 49 (9), 979-991.(link)
  28. Lakerveld, R.; Kuhn, J.; Kramer, H. J. M.; Jansens, P. J.; Grievink, J. Membrane assisted crystallization using reverse osmosis: Influence of solubility characteristics on experimental application and energy saving potential. Chemical Engineering Science 2010, 65 (9), 2689-2699.(link)
  29. Lakerveld, R.; Kramer, H. J. M.; Jansens, P. J.; Grievink, J. The application of a task-based concept for the design of innovative industrial crystallizers. Computers & Chemical Engineering 2009, 33 (10), 1692-1700.(link)
  30. Kuhn, J.; Lakerveld, R.; Kramer, H. J. M.; Grievink, J.; Jansens, P. J. Characterization and Dynamic Optimization of Membrane-Assisted Crystallization of Adipic Acid. Industrial Engineering Chemistry Research. 2009, 48 (11), 5360-5369.(link)
  31. Lakerveld, R.; Bildea, C. S.; Almeida-Rivera, C. P. Exothermic isomerization reaction in a reactive flash: Steady-state behavior. Industrial Engineering Chemistry Research. 2005, 44 (10), 3815-3822.(link)

Book chapters:

  1. Kramer, H.J.M.; Lakerveld, R. Selection and design of industrial crystallizers. Chapter 5 in Handbook of Industrial Crystallization, 3rd edition, Cambridge University Press, 2019, in press, ISBN: 9781139026949.
  2. Lakerveld, R.; Control system implementation and plant-wide control of continuous pharmaceutical manufacturing pilot plant (end-to-end manufacturing process). Chapter 16 in Process Systems Engineering for Pharmaceutical Manufacturing. Elsevier, 2018, ISBN: 978-0-444-63963-9.
  3. Lakerveld, R.; Heider, P. L.; Jensen, K. D.; Braatz, R. D.; Jensen, K. F.; Myerson, A. S.; Trout, B. L.; End-to-End Continuous Manufacturing: Integration of Unit Operations. Chapter 13 in Continuous Manufacturing of Pharmaceuticals. Wiley-Blackwell, 2017, ISBN: 978-1-119-00132-4.
  4. Khodadadian, F.; Nasalevich, M.; Kapteijn, F.; Stankiewicz, A.I.; Lakerveld, R.; Gascon, J. Photocatalysis: Past achievements and future trends. Chapter 8. RSC Green Chemistry. Volume 2016-January, Issue 47, 2016, Pages 227-269.

Invited lectures:

  1. Lakerveld, R. Industrial crystallization of Pharmaceuticals. East China University of Science and Technology, Shanghai, China, June 6, 2018.
  2. Lakerveld, R. Continuous Pharmaceutical Crystallization. 2018 International Forum on Crystal Engineering & Smart manufacturing (CESM2018), Tianjin, China, 2018.
  3. Lakerveld, R. Industrial crystallization of (bio)pharmaceuticals. Tianjin University and Hebei University of Technology, Tianjin, China, January 8, 2018.
  4. Lakerveld, R. Future directions in the manufacture of (bio)pharmaceuticals: continuous pharmaceutical crystallization and electric-field-assisted protein crystallization. Asian Dean's Forum Workshop on Bioengineering , NUS, Singapore, March 12, 2017.
  5. Lakerveld, R. Continuous Crystallization of Pharmaceuticals, Collaborative Conference on Crystal Growth, Hong Kong, December 14, 2015.
  6. Lakerveld, R.; Benyahia, B.; Heider, P.L.; Zhang, H.; Wolfe, A.; Testa, C.J.; Ogden, S.; D.R. Hersey; Mascia, S.; Evans, J.M.B.; Braatz, R.D.; Barton, P.I. The application of a plant-wide control strategy for an integrated continuous pharmaceutical pilot plant. SMi Quality by Design. London, UK, February 11, 2014.
  7. Lakerveld, R.; Benyahia, B.; Heider, P.L.; Zhang, H.; Mascia, S.; Evans, J.M.B.; Braatz, R.D.; Barton, P.I. A Plant-wide Control Strategy for an Integrated Continuous Pharmaceutical Pilot Plant. Pharma IQ’s 10th Annual PAT and Quality by Design Conference. London, UK, March 19, 2013.
  8. Lakerveld, R.; Benyahia, B.; Heider, P.L.; Zhang, H.; Mascia, S.; Evans, J.M.B.; Braatz, R.D.; Barton, P.I. The Application of a Plant-wide Control Strategy for a Continuous Pharmaceutical Process at the Novartis-MIT Center for Continuous Manufacturing. The University of Heidelberg International QbD / PAT Conference, Heidelberg, Germany, September 2012.
  9. Lakerveld, R.; Soare, A.; Kramer, H.J.M.; Stankiewicz, A.I. Opportunities for Process Intensification of Solution Crystallization. Japanese-Netherlands Conference on Crystal Growth, Sendai, Japan, July 2012.
  10. Lakerveld, R.; Evans, J.M.B.; Benyahia, B.; Braatz, R.D.; Barton, P.I. Implementing Continuous Manufacturing: The synergy between plant-wide control, modeling, and QbD. International Pharma QbD Forum, Berlin, Germany, April 2012.
  11. Lakerveld, R.; Kramer, H.J.M.; Jansens, P.J.; Grievink, J. Application of Task-Based Design for Solution Crystallization: Air Mixed Devices, Seeding, Ultrasound & Membranes. Group Users of Technology for Separation in the Netherlands (NLGUTS), Delft, The Netherlands, October 2009.
  12. Lakerveld, R. Kramer, H.J.M., Jansens, P.J. Grievink, J. Task Based Design Techniques for Solution Crystallization Processes. BASF Crystallization Symposium, Ludwigshafen, Germany, August 2008.
  13. Lakerveld, R., Kramer, H.J.M., Jansens, P.J., Grievink, J. Task Based Design Techniques for Solution Crystallization Processes. DSM Research & Technology, Geleen, The Netherlands, May 2008.

Selected papers in conference proceedings:

  1. Gao, Y.; Lakerveld, R. Experimental Validation of Scheduled PID Control for Directed Self-Assembly of Colloidal Particles in Microfluidic Devices. Proceedings of the 13th International Symposium on Process Systems Engineering (PSE2 018), July 1 - July 4, 2018, San Diego, CA, USA, 2455–2460.
  2. Wang, J.; Lakerveld, R. Integrated Solvent and Process Optimization Using PC-SAFT for Continuous Crystallization with Energy-intensive Solvent Separation for Recycling. Proceedings of the 13th International Symposium on Process Systems Engineering (PSE2 018), July 1 - July 4, 2018, San Diego, CA, USA, 1051–1056.
  3. R. Lakerveld, B. Benyahia, P.L. Heider, H. Zhang, A. Wolfe, C.J. Testa, S. Ogden, D.R. Hersey, S. Mascia, J.M.B. Evans, R.D. Braatz, P.I. Barton, The Application of an Automated Plant-wide Control Strategy for a Continuous Pharmaceutical Pilot Plant. Proceedings of the 2014 American Control Conference, June 04-June 06, 2014, Portland, Oregon, USA, 3512-3517.
  4. R. Lakerveld, G. Stephanopoulos, P.I. Barton, Robust fabrication of non-periodic nanoscale systems via directed self-assembly. Computer-Aided Chemical Engineering 29, 2011, 1603-1607.
  5. R. Lakerveld, H.J.M. Kramer, P.J. Jansens, J. Grievink, The application of a task-based concept for design of innovative industrial crystallizers. PSE 2009 Conference Proceedings, Salvador, Brazil, 2009.
  6. R. Lakerveld, H.J.M. Kramer, A.I. Stankiewicz, P.J. Jansens, J. Grievink, Opportunities for process intensification in crystallization: application of air-mixed devices, ultrasound & membranes. EPIC 2009 Conference Proceedings, Venice, Italy, 2009.
  7. R. Lakerveld, H.J.M. Kramer, P.J. Jansens and J. Grievink, The Application of a Task Based Design Approach to Solution Crystallization. FOCAPD Conference Proceedings, Breckenridge, Colorado, United States, 2009.
  8. R. Lakerveld, H.J.M. Kramer, P.J. Jansens, J. Grievink, A task based design approach for solution crystallization. BIWIC 2008 Conference Proceedings, Magdeburg, Germany, 2008, 95-102.
  9. R. Lakerveld, H.J.M. Kramer, P.J. Jansens, J. Grievink, A Task Based Design Approach for Solution Crystallization. 17th International Symposium on Industrial Crystallization Conference Proceedings, Maastricht, The Netherlands, 2008, 27-34.
  10. R. Lakerveld, H.J.M. Kramer, P.J. Jansens, J. Grievink, Solution Crystallization in a Bubble Column. Optimization of the task: Crystal Growth, 17th International Symposium on Industrial Crystallization Conference Proceedings, Maastricht, The Netherlands, 2008, 819-826.
  11. R. Lakerveld, J. Kuhn, M.A. Bosch, H.J.M. Kramer, P.J. Jansens, J. Grievink,  Membrane Assisted Evaporative Crystallization: Optimization of Task Supersaturation Generation, 17th International Symposium on Industrial Crystallization Conference Proceedings, Maastricht, The Netherlands, 2008, 827-834.
  12. R. Lakerveld, P.G. Verzijden, H.J.M. Kramer, P.J. Jansens, J. Grievink, The Application of Ultrasound for Seeding Purposes Optimization of the task: Nucleation, 17th International Symposium on Industrial Crystallization Conference Proceedings, Maastricht, The Netherlands, 2008, 835-842.
  13. R. Lakerveld, H.J.M. Kramer, P.J. Jansens, J. Grievink, The application of a task-based concept for the design of innovative industrial crystallizers. 18th European Symposium on Computer Aided Process Engineering Conference Proceedings, Lyon, France 2008, 103-108.
  14. R. Lakerveld, A.N. Kalbasenka, H.J.M. Kramer, P.J. Jansens, J. Grievink, The application of different seeding techniques for solution crystallization of ammonium sulphate. BIWIC 2007 Conference Proceedings, Cape Town, South Africa, 2007, 221-228.
  15. R. Lakerveld, M.E. Djatmiko, H.J.M. Kramer, P.J. Jansens, J. Grievink, Task based design techniques for solution crystallisation processes: application to a bubble column setup. BIWIC 2006 Conference Proceedings, Delft, The Netherlands, 2006, 114 – 121.

Links:

News

Vacancies

Postdoctoral Associate

We have open vacancies in our group for Postdoctoral Associates in the general research areas of continuous pharmaceutical crystallization and automated control and optimization of directed self-assembly. Recruitment is year-round with starting date preferable before August 2019. Candidates should be highly motivated and should have a PhD degree in chemical engineering or related discipline with experience in one or more of the following areas: process systems engineering, crystallization, directed self-assembly, process control, or process optimization. The postdoctoral researcher is expected to lead his/her project and to train students working in the lab. This is a one-year term appointment with the possibility of renewal based upon satisfactory job performance and continuing availability of funds. Salary will be commensurate with qualifications and experience. Qualified candidates should send a brief description of their research interests and previous research experience along with their CV including the contact details of two or three referees to kelakerveld@ust.hk.

Postgraduate Students

Vacancies for fully funded postgraduate positions are available (PhD or MPhil)! If you have shown academic excellence at a reputable university, are highly motivated, and you have an interest in Chemical Engineering in general, and in the research of our group in particular, please contact Prof. Lakerveld directly for enquiries.

HKUST is a modern, English-speaking, top-ranked University in Asia. HKUST’s School of Engineering consistently ranks among the top 25 programs in the world. Prof. Lakerveld’s research interests are in the field of Process Systems Engineering. In particular, the focus of the group is on the design and control of processes that involve the production of structured materials. Such processes are typically driven by crystallization or directed self-assembly. Research interests span from controlled assembly of individual building blocks into specific structures on a small scale to optimal integration of unit operations into continuous pharmaceutical manufacturing systems on a large scale.

Candidates should have a BEng or MSc degree (or equivalent) in chemical engineering or related discipline. Sufficient proficiency in the English language is required as demonstrated by an internationally recognized English test score. Extracurricular activities and international exposure are appreciated.

Contact

HKUST campus

Richard Lakerveld
The Hong Kong University of Science and Technology
Department of Chemical and Biological Engineering
Clear Water Bay, Kowloon, Hong Kong
Email: kelakerveld@ust.hk
Room: CYT2003 (lift 35/36)
Phone: (852) 3469 2217

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